CBioProfiler:癌症生物标志物和亚型表征的网络和独立管道
Xiaoping Liu1,2,3, Zisong Wang1, Hongjie Shi3,4
1Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Genomics, proteomics & bioinformatics
|June 13, 2024
概括
一个新的工具,癌症生物标志物和亚型分析仪 (CBioProfiler),有助于识别癌症生物标志物和亚型,以预测患者的生存率. 该资源提供标准化管道和精选数据,以改善癌症研究和临床应用.
科学领域:
- 在瘤学瘤学.
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
背景情况:
- 癌症仍然是全球主要的健康挑战,需要准确预测患者的生存率,以获得有效的治疗和预后.
- 目前用于探索癌症生物标志物和亚型的工具缺乏标准化,阻碍了研究和临床应用.
研究的目的:
- 推出癌症生物标志物和亚型分析师 (CBioProfiler),一个新的网络服务器和独立应用程序.
- 为分析癌症生物标志物和亚型提供标准化管道,以预测患者的生存率.
主要方法:
- 开发了两个不同的管道:一个用于使用机器学习识别和注释癌症生物标志物,另一个用于使用无监督学习识别癌症亚型.
- 综合精选的癌症预后数据 (Integrated CuratedCancerPrognosisData) 是一个R包,包含精选的基因表达和来自268项研究的临床数据,涵盖43种瘤类型和47686个样本.
主要成果:
- CBioProfiler提供了一个全面的平台,用于分析与癌症存活相关的生物标志物,并识别不同的癌症亚型.
- 综合数据集为验证广泛癌症类型的发现提供了强大的资源.
结论:
- CBioProfiler解决了癌症生物标志物和亚型分析中标准化工具的需求.
- 该资源有助于改善癌症患者的风险分层,治疗选择和预后评估.
相关概念视频
02:26Protein Networks
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
02:07Tumor Progression
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
01:33Cancer-Critical Genes I: Proto-oncogenes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...