大面积机器人辅助光学连贯性断层扫描 (LARA-OCT)
Simon Lotz1, Madita Göb1, Sven Böttger2,3
1Institute of Biomedical Optics, Universität zu Lübeck, Peter-Monnik-Weg 4, 23562 Lübeck, Germany.
Biomedical optics express
|June 13, 2024
概括
大面积机器人辅助光学连贯性断层扫描 (LARA-OCT) 能够对大而曲的表面进行成像. 该系统集成了机器人臂和MHz-OCT,用于高效,高分辨率的扫描,无需外部跟踪.
科学领域:
- 生物医学工程 生物医学工程
- 光学成像技术的成像
- 机器人技术 机器人技术 机器人技术
背景情况:
- 传统的光学连贯性断层扫描 (OCT) 仅限于小的平面样本区域.
- 绘制大型或任意形状的表面图像,如生物组织,需要先进的扫描技术.
- 现有的方法往往需要复杂的外部机器视觉系统来跟踪和注册.
研究的目的:
- 开发和演示一个大面积的机器人辅助光学连贯性断层扫描 (LARA-OCT) 系统.
- 为了在扩展和非平面样本区域上实现OCT高分辨率成像.
- 整合机器人控制和OCT成像,以简化数据采集.
主要方法:
- 使用7度自由度的机器人手臂与3.3MHz扫描源OCT相结合.
- 实施了光扫描策略,通过结合多个视野 (FOV) 来覆盖任意样本形状.
- 开发了使用OCT图像数据进行直角对齐的实时探测到表面的控制,消除了对外部机器视觉的需求.
主要成果:
- 成功展示了LARA-OCT用于成像大面积样本,包括像皮肤这样的曲表面.
- 实现了高效的数据采集,在2.5分钟内捕获140 × 170 × 20 mm3体积的数据集.
- 消除了单独的摄像头,定位,跟踪或导航设备的要求,通过集成的基于OCT的跟踪和拼接.
结论:
- 拉拉-OCT显著扩大了OCT可实现的成像区域,克服了传统系统的局限性.
- 综合方法简化了成像工作流程,并减少了硬件复杂性.
- 这种技术非常适合用于各种样本几何形状的高分辨率,大体积成像.
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