人体皮肤中光散射特性与该人的年龄的相关性,使用非侵入性技术进行评估
Neža Golmajer Zima1,2, Nina Verdel1, Boris Majaron1,2
1Department of Complex Matter, Jožef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia.
Biomedical optics express
|June 13, 2024
概括
衰老显著降低皮肤的减少散射系数,但不是表皮. 这项研究使用非侵入性方法量化了与年龄相关的皮肤光学特性变化.
科学领域:
- 生物医学光学 生物医学光学
- 皮肤病学 皮肤病学
- 生物物理学的生物物理.
背景情况:
- 皮肤老化会影响光学特性,影响基于光的医学治疗.
- 量化皮肤光学特性与年龄相关的变化对于准确的诊断和治疗至关重要.
研究的目的:
- 研究衰老对人类皮肤表皮和皮肤外皮的光学特性的影响.
- 为了确定降低散射系数和层厚度的与年龄相关的变化.
主要方法:
- 使用了一种非侵入性技术,结合了脉冲光热放射测量和扩散反射光谱.
- 采用蒙特卡洛模型,在四层皮肤模型中运输光.
- 分析了黑色素和血液含量对光学特性的影响.
主要成果:
- 随着年龄的增长,皮肤减少散射系数 (a_der) 显著下降 (平均速率为每十年-0.25 mm-1).
- 乳头皮肤中的血液含量有显著的贡献 (1.0 mm-1%-1).
- 在表皮减少散射系数 (a_epi) 或表皮和皮肤厚度上没有发现与年龄有关的影响.
结论:
- 皮肤的光学特性随着年龄的增长而发生显著变化,主要是由于血液含量减少.
- 外皮的光学特性和皮肤层厚度在很大程度上不受年龄的影响.
- 这些发现为与年龄相关的皮肤光学建模提供了必要的数据.
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