降脂方法来管理他类药物不耐受的患者
Massimiliano Ruscica1,2, Alessandra Bertoletti2, Cecilia Gobbi2
1Department of Pharmacological and Biomolecular Sciences 'Rodolfo Paoletti', Università degli Studi di Milano, Milan.
概括
达丁类药物不耐受性影响高达60%的患者,增加心血管风险. 对于那些无法耐受他类药物的人来说,存在其他降低LDL-C的疗法.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 类药物广泛用于通过降低低密度脂蛋白胆固醇 (LDL-C) 来预防心血管疾病 (CVD).
- 由于不耐受性,高水平的他类药物不服药率 (高达60%) 将心血管疾病事件的风险增加70%.
- 达他林不耐受,通常是由于肌肉症状,限制有效的LDL-C降低.
研究的目的:
- 在心血管疾病预防中审查他类药物不耐受性的挑战.
- 为了突出替代性降脂策略对于他类药物不耐受的患者.
- 强调LDL-C降低对于心血管风险管理的重要性.
主要方法:
- 关于他类药物的疗效,不耐受性和替代治疗方法的文献综述.
- 对他类药物不服药对心血管结果的影响分析.
- 在LDL-C管理方面,除了他类药物之外,目前的治疗选择概述.
主要成果:
- 立方体不耐受是预防心血管疾病的重要障碍,肌肉症状是主要原因.
- 任何LDL-C降低,无论药物如何,都会为心血管提供好处.
- 对于对他类药物不耐受的患者,有几种替代性降低LDL-C的策略可供选择.
结论:
- 有效管理心血管风险需要解决他类药物不耐受症.
- 替代疗法,如埃泽提米布,贝佩多酸和PCSK9抑制剂提供了可行的选择.
- 实现治疗性LDL-C目标对于减少动脉样硬化心血管疾病事件至关重要.
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