一种低膨胀的水凝作为多功能密封剂,用于有效的持续缺陷密封和预防术后粘附
Xueliang Cheng1,2, Zhen Zhang1, Hui Ren1,3
1CAS Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
National science review
|June 13, 2024
概括
一种新的水凝密封剂有效地密封持续缺陷,防止神经外科手术后脑脊液 (CSF) 泄漏. 这种创新的材料减少了炎症和粘附,为手术并发症提供了有前途的解决方案.
科学领域:
- 生物材料科学 生物材料科学
- 神经外科 神经外科
- 组织工程是组织工程.
背景情况:
- 持续性缺陷在脊柱和神经外科手术中很常见,导致脑脊液 (CSF) 泄漏.
- 目前对持久缺陷的治疗方法往往不令人满意,需要改进密封解决方案.
研究的目的:
- 开发和评估一种新的组织粘合剂,低膨胀的水凝密封剂,用于长时间的缺陷封闭.
- 在临床前模型中评估水凝的机械性能,密封效率和生物相容性.
主要方法:
- 一种水凝密封剂是通过OPA/氨基凝结合成的,使用凝和o-phthalaldehyde (OPA) 终结的4臂聚乙烯甘醇 (4aPEG-OPA) 合成的.
- 测量了水凝的粘合强度和破裂压力.
- 评估了水凝的胀行为,老鼠和子持续缺陷模型中的密封性能,以及对炎症和粘附的影响.
主要成果:
- 4aPEG-OPA/凝水凝显示出显著的粘合强度 (79.9 ± 12.0 kPa) 和破裂压力 (208.0 ± 38.0 cmH2O).
- 水凝呈现出较低的胀,防止神经压缩.
- 在动物模型中,有效地封闭了持续缺陷,并防止了脑脊髓液的泄漏,减少了炎症和粘附.
结论:
- 开发的4aPEG-OPA/凝水凝显示出强大的潜力,作为一种有效的密封剂,用于长期缺陷的防水封闭.
- 这种水凝提供了一个有前途的解决方案,以减少与神经外科和脊椎外科手术中持续缺陷相关的并发症.
相关概念视频
Adhesion
Adhesion occurs when one type of molecule is attracted to a different molecule. Water exhibits adhesive properties in the presence of polar surfaces, such as glass or cellulose in plants. For instance, when water is poured into a glass, the positively charged hydrogen molecules of water are more attracted to the negatively charged oxygen molecules in the silica than to the oxygen in neighboring water molecules.
Capillary action is a result of water’s adhesive tendencies. When a narrow glass...
Capillary action is a result of water’s adhesive tendencies. When a narrow glass...
Tight Junctions
Tight junctions are molecular seals between cells that prevent the leaking of fluids, ions, and other small solutes across cavities and compartments in multicellular organisms. They are mainly composed of claudin and occludin transmembrane proteins, and other proteins such as tricellulin and JAM (junctional adhesion molecule). All these proteins are 4-pass transmembrane proteins, except JAM, which is a single-pass transmembrane protein belonging to the immunoglobulin superfamily. The...
Retarders
Retarders are chemical admixtures designed to extend the setting time, which is especially useful when there is a delay in sequential concrete pours to prevent cold joints and to achieve a cohesive structure. Retarders, when used in appropriate amounts, can also enhance the architectural appearance of exposed aggregate finishes.
The function of retarders is to delay the setting of concrete, and this effect can be measured using a penetration test. The retardation process involves adding...
The function of retarders is to delay the setting of concrete, and this effect can be measured using a penetration test. The retardation process involves adding...
Plasticizers
Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Superplasticizers
Superplasticizers are advanced admixtures that enhance the workability of concrete by lowering the water content without compromising the strength of the material. These substances are highly effective water reducers, improving concrete flow, making it easier to work with, and enabling concrete to reach inaccessible areas or densely reinforced sections without mechanical vibration. The key components in superplasticizers are either sulfonated melamine or naphthalene formaldehyde condensates,...
Waterproofing and Anti-Bacterial Admixtures in Concrete
Concrete's susceptibility to water absorption is due to the capillary action within the pores of its hydrated cement paste. This action draws water in, creating the need for waterproofing admixtures to prevent such penetration. The efficacy of these admixtures is contingent upon the water pressure, with variations arising from different conditions such as rain, capillary rise, or hydrostatic pressure in structures intended to hold water.
Waterproofing admixtures render concrete hydrophobic,...
Waterproofing admixtures render concrete hydrophobic,...


