长期淋巴缺血和预后在住院患者与不同的呼吸道病毒感染:一个回顾性队列研究
Guohui Fan1,2, Wuyue Yang3, Dingyi Wang2
1School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, State Key Laboratory of Respiratory Health and Multimorbidity, Key Laboratory of Pathogen Infection Prevention and Control (Peking Union Medical College), Ministry of Education, PR China.
长时间的淋巴缺血症显著增加了流感和SARS-CoV-2感染患者的死亡风险. 在其他呼吸道病毒感染中没有观察到这种定量风险,突出了特定的预后因素.
科学领域:
- 医学研究 医学研究
- 传染病 传染病 传染病
- 血液学 血液学 血液学
背景情况:
- 淋巴缺血是呼吸道病毒感染中常见的发现,但从量上来看,它与患者的病情不佳无关.
- 了解淋巴缺血持续时间的预后价值对于管理呼吸道病毒感染至关重要.
研究的目的:
- 量化评估长期淋巴缺血对流感,SARS-CoV-2和其他呼吸道病毒感染患者的住院死亡率和临床结果的影响.
主要方法:
- 一项回顾性队列研究,涉及2388名实验室确认的呼吸道病毒感染的成年住院患者.
- 分析包括连续的实验室数据,重点关注淋巴缺血的持续时间和在医院的所有死因.
- 统计方法包括莱根德尔直角多项式,受限制的立方线和多变量逻辑回归.
主要成果:
- 长时间的淋巴缺血 (持续时间>3天) 与流感和SARS-CoV-2感染的住院死亡率增加显著相关.
- 患有流感的患者经历了长达7天的淋巴缺血,死亡风险增加了17.80倍.
- 同样,SARS-CoV-2患者的淋巴缺血>7天的死亡风险增加了6.28倍. 长时间的淋巴缺血也与这些群体的多器官损伤相关.
- 在患有其他呼吸道病毒的患者中,长期淋巴缺血和不良结果之间没有发现显著的关联.
结论:
- 长时间的淋巴缺血是更糟糕的临床预后和流感和SARS-CoV-2感染中的死亡率的重要独立预测因素.
- 淋巴缺血的持续时间是确定特定呼吸道病毒感染患者结果的关键因素.
- 这些发现强调了监测流感和SARS-CoV-2住院患者的淋巴细胞计数的重要性.
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