多发性硬化症 (MS) 疾病修饰疗法 (DMT) 的知识映射:一个参考资料分析
Fan Jiang1,2,3, Fenghe Zhang4, Yue Su1
1Department of Neurology, Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
Heliyon
|June 13, 2024
概括
这项研究分析了多发性硬化症疾病修饰疗法 (DMT),综合了新兴,传统和交叉治疗的文献. 未来的研究应该专注于组合试验和针对多发性硬化症患者的个性化药物.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 多发性硬化症 (MS) 是一种复杂的自身免疫性疾病,研究领域正在迅速扩大.
- 综合和组织关于MS疾病修饰疗法 (DMT) 的大量文献至关重要.
研究的目的:
- 对MS的新兴,传统和跨领域的DMT进行文献计量分析.
- 确定当前的研究趋势和MS治疗的未来方向.
主要方法:
- 从Web of Science核心收藏中对4142 (e-DMT),6521 (t-DMT) 和1793 (I-DMT) 出版物的图书法分析.
- 数据使用VOSviewer,Citespace,R包"Bibliometrix"和Scimago Graphica.com进行分析.
- 利用最大概率 (LLR) 聚类和爆发引用算法.
主要成果:
- 确定了关键的研究主题,包括COVID-19 mRNA疫苗安全性,治疗惯性,克拉迪宾片,自身造血干细胞移植 (aHSCT),渐进性MS和儿科MS.
- 对国家,机构,作者,关键词和参考进行了描述和预测分析.
结论:
- 未来的MS DMT研究应该优先考虑组合试验和交叉试验,以制定个性化的治疗计划.
- 关键领域包括单克隆抗体,克拉迪宾,aHSCT,mRNA COVID-19疫苗的影响,治疗惯性,患者坚持和生物标志物发现.
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