对病毒和微生物群的抗体特征反映了过去和慢性暴露,并与衰老和炎症有关
Sergio Andreu-Sánchez1,2, Aida Ripoll-Cladellas3, Anna Culinscaia1
1Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
iScience
|June 13, 2024
概括
接触诸如细胞大脑病毒 (CMV) 和常见病毒等微生物会影响免疫系统的衰老和炎症. 对病原体的抗体反应与端粒长度相关,揭示了过去感染和生物衰老之间的联系.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
- 衰老研究研究 衰老研究
背景情况:
- 免疫系统对病原体的反应具有持久的生理影响.
- 不同微生物暴露对人类健康的集体影响仍然不完全理解.
- 了解这些相互作用对于理解生物衰老和炎症至关重要.
研究的目的:
- 研究过去的微生物暴露与生物衰老之间的关系.
- 探索这些暴露对炎症和免疫细胞组成的影响.
- 识别与衰老标志物和炎症概况相关的特定病原体.
主要方法:
- 针对来自微生物,病毒和环境来源的2815种的抗体结合谱进行分析.
- 分析了来自1443名参与者的人口队列的数据.
- 使用抗体结合作为历史病原体暴露的代理,并与生物衰老标志物和单细胞免疫特征相关联.
主要成果:
- 对细胞巨乳病毒 (CMV),鼻病毒和肠道细菌的免疫反应与端粒长度有关.
- 细胞巨乳病毒 (CMV) 感染明显改变了CD8和CD4T细胞亚群的转录格局.
- 慢性感染 (CMV,爱斯坦-巴尔病毒) 和常见的病原体 (鼻病毒,腺病毒C) 与生物衰老和炎症有关.
结论:
- 抗体概况是过去暴露和它们对衰老的影响的有价值指标.
- 特定的病毒和细菌暴露,特别是慢性感染,显著影响免疫衰老和炎症.
- 这项研究提供了对微生物接触的长期健康后果的见解.
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