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Updated: Jul 19, 2026

Cell Lineage Analyses and Gene Function Studies Using Twin-spot MARCM
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Sarcoma_CellminerCDB:一种工具,用于查询综合收集的肉瘤细胞系的基因组和功能特征

Camille Tlemsani1,2,3, Christine M Heske4, Fathi Elloumi1

  • 1Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.

iScience
|June 13, 2024
PubMed
概括

研究人员开发了Sarcoma_CellMinerCDB,这是一个新工具,集成了133种肉 Sarcoma 细胞系的各种 omics 数据. 本资源旨在通过使假设测试和问题产生来推进临床前肉瘤研究.

关键词:
癌症 癌症 癌症 癌症癌症系统生物学癌症系统生物学细胞生物学 细胞生物学基因组学就是基因组学.蛋白质组学是指蛋白质组学.文字转录学 (Transcriptomics) 是一个学科.

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...