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16阳性HPV/ASC-H宫癌查结果是否比其他高风险HPV亚型更好地预测CIN 2+?

Abdurrahman Alp Tokalıoğlu¹, Aysun Alcı², Okan Oktar³

¹Clinic of Gynecologic Oncology, University of Health Sciences Turkey, Ankara City Hospital, Ankara, Turkey.

Journal of the Turkish German Gynecological Association

|June 13, 2024

概括

高风险人类乳头瘤病毒 (HPV) 阳性,特别是HPV 16,与ASC-H细胞学患者的CIN 2+病变有显著的相关性. 这一发现凸显了HPV检测在管理ASC-H结果中对于早期检测高度发育不良的重要性.

科学领域:

妇科瘤学妇科瘤学
宫病理学宫病理学
病毒学病毒学

背景情况:

非典型的状细胞,不能排除高度状细胞内瘤 (ASC-H) 是需要进一步调查的细胞学发现.
高风险人类乳头瘤病毒 (HPV) 测试在管理ASC-H病例中的作用需要澄清.

研究的目的:

调查高风险HPV类型与ASC-H细胞学患者宫内皮质瘤2级或更高 (CIN 2+) 病变的存在之间的相关性.

主要方法:

从2003年至2021年间接受了大肠镜检查的5271名患者的数据的回顾性分析.
专注于163名ASC-H细胞学患者,其中包括83例HPV阳性病例.
在HPV状态 (特别是HPV 16) 和最终病理学结果 (CIN 2+) 之间的相关性分析.

主要成果:

在患者年龄和CIN 2+病变之间没有发现显著的相关性 (p=0.053).
阳性HPV16 (单独或与其他类型一起) 显著增加了最终病理中CIN 2+病变的可能性.
在HPV16阳性ASC-H患者中,CIN 2+病变的概率为72.5%,而在HPV16阴性患者中为48.1% (p=0.033).

结论:

目前的指南缺乏在ASC-H管理中对HPV检测的全面定义.
积极的高风险HPV结果,特别是HPV 16,与ASC-H细胞学结合,表明高度发育不良的可能性更高.
对HPV检测,特别是对HPV 16的检测,是评估ASC-H病例中显著宫病理的风险的一个有价值的工具.

关键词:

在ASC-H中,它是ASC-H.在HPV中,HPV是HPV.宫癌:子宫癌是一种癌症.

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