黑米饮食通过调节二甲酸代谢和激活AHR通路来缓解结直肠癌的发展
Ling Wang1,2,3,4, Yi-Xuan Tu1,2,3, Lu Chen1
1Hubei Hongshan Laboratory, Hubei Key Laboratory of Agricultural Bioinformatics, Hubei Key Laboratory of Metabolic Abnormalities and Vascular Aging, College of Life Science and Technology, College of Biomedicine and Health, Interdisciplinary Sciences Institute Huazhong Agricultural University Wuhan China.
iMeta
|June 13, 2024
概括
黑米饮食 (BRD) 在小鼠中显示出对结肠直肠癌 (CRC) 的抗瘤原源作用. 这种全谷物饮食促进有益的肠道细菌和代谢物,减少瘤生长并改善生存率.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
背景情况:
- 食纤维和酸与降低结直肠癌 (CRC) 风险有关.
- 黑米富含这些有益的化合物,表明潜在的健康益处.
研究的目的:
- 研究黑米饮食 (BRD) 对结直肠癌的抗瘤作用.
- 探索BRD对肠道微生物群,代谢物和肠道健康的影响.
主要方法:
- 给小鼠食BRD或对照饮食,并监测瘤的发展.
- 便微生物群移植从BRD养的小鼠进行到无细菌的小鼠.
- 分析了肠道微生物组成,代谢物和结肠细胞增殖.
主要成果:
- BRD显著减少了肠道瘤的大小和数量,延长了小鼠的寿命.
- 来自BRD养小鼠的便移植减少了结肠细胞的增殖,并保持了肠道屏障的完整性.
- BRD改变了肠道微生物群,增加了诸如*Bacteroides uniformis*和*Lactobacillus*之类的有益细菌,并上调了诸如醇-3-乳酸和醇等保护性代谢物.
结论:
- 黑米饮食对结直肠癌具有显著的抗瘤原源性质.
- BRD调节肠道微生物群和代谢物概况,有助于抑制结直肠瘤发生.
- 这些发现强调了全谷物,特别是黑米在预防癌症方面的健康益处.
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