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相关概念视频

Genomics02:02

Genomics

36.3K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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The Central Dogma01:20

The Central Dogma

21.3K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
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Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Ribosome Profiling02:24

Ribosome Profiling

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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
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Genome Annotation and Assembly03:36

Genome Annotation and Assembly

18.8K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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相关实验视频

Updated: Jun 24, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

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解码微生物基因组,以了解它们在人类复杂疾病中的功能作用.

Yifeng Wang1,2, Quanbin Dong1,2, Shixian Hu3

  • 1Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University Nanjing Medical University Nanjing Jiangsu China.

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概括

肠道微生物组显著影响诸如心血管疾病和癌症等复杂疾病. 了解其功能作用和解码微生物基因组是开发个性化医学策略的关键.

关键词:
复杂的疾病复杂的疾病.我们的肠道微生物组.主体微生物的相互作用.代谢产物的代谢产物

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Purifying the Impure: Sequencing Metagenomes and Metatranscriptomes from Complex Animal-associated Samples
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Microbial Communities in Nature and Laboratory - Interview
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科学领域:

  • 微生物组研究的研究.
  • 复杂疾病病因 复杂疾病病因学
  • 基因组学就是基因组学.

背景情况:

  • 复杂疾病 (如心血管疾病,肥胖,癌症) 影响全球超过20%的人口.
  • 传统上归因于遗传学和环境,复杂疾病的起源越来越多地与肠道微生物组的代谢功能有关.
  • 肠道微生物群对宿主健康和疾病的作用是一个日益增长的研究领域.

研究的目的:

  • 审查肠道微生物组对人类复杂疾病的功能性贡献.
  • 引入用于解码微生物基因组和评估其功能的计算工具.
  • 突出了解肠道微生物组的机械作用和推进个性化医学的先进技术.

主要方法:

  • 文献综述侧重于肠道微生物群在复杂疾病中的功能性作用.
  • 对微生物基因组分析的生物信息学工具和人工智能的概述.
  • 讨论用于对宿主微生物群相互作用的机械洞察的尖端技术.

主要成果:

  • 肠道微生物组的代谢输出是许多复杂疾病的发病的一个关键因素.
  • 基因组分析工具使微生物功能潜力的全面分析成为可能.
  • 新兴技术为阐明微生物组与疾病之间的因果关系提供了途径.

结论:

  • 肠道微生物群在复杂疾病中起着重要作用,需要对其功能机制进行进一步的研究.
  • 解码微生物基因组及其功能对于理解疾病发展至关重要.
  • 微生物组研究的进步为针对微生物组的诊断和个性化治疗策略铺平了道路.