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在患有多囊性卵巢综合征的妇女中,母亲的甲状腺功能和后代出生人体测量

Anastasia Trouva¹, Michael Alvarsson¹, Jan Calissendorff¹

¹Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Frontiers in endocrinology

|June 13, 2024

概括

孕产妇的甲状腺功能会影响多囊性卵巢综合征 (PCOS) 的妇女的新生儿大小. 较高的自由甲状腺素 (fT4) 与较小的婴儿有关,而甲状腺刺激激素 (TSH) 水平影响了对妊娠年龄 (LGA) 大的风险.

科学领域:

生殖内分泌学生殖内分泌学
孕产妇和胎儿医学孕产妇和胎儿医学
内分泌学在内分泌学.

背景情况:

多囊卵巢综合征 (PCOS) 和甲状腺疾病与不良怀孕和新生儿后果有关.
母体甲状腺功能的微妙变化可能会影响胎儿的生长,即使在正常范围内.

研究的目的:

为了调查孕妇患有PCOS的母亲甲状腺功能和新生儿人类学之间的联系.
探索甲胺对这些关联的潜在修饰作用.

主要方法:

对两项随机对照试验 (RCT) 的后期分析,涉及使用甲福尔或安慰剂治疗的孕妇患有PCOS.
母体血清甲状腺刺激激素 (TSH) 和自由甲状腺素 (fT4) 水平在多个时间点被测量.
使用回归模型分析了后代的人类测量 (出生体重,出生长度,头周长) 和结果,如对妊娠年龄大 (LGA) 和对妊娠年龄小 (SGA).

主要成果:

怀孕早期母亲的fT4与出生长度有负相关性,而fT4的变化与出生体重和长度z-score有正相关性.
TSH水平与LGA风险相反相关,而TSH的变化与LGA积极相关.
在TSH和SGA之间,以及在ΔfT4和SGA之间,只有在甲胺组中观察到特定的反向关联.

结论:

孕产妇甲状腺功能,特别是fT4和TSH水平及其在怀孕期间的变化,与患有PCOS的妇女的后代人体测量有关.
母体甲状腺功能的亚临床变化可能在确定PCOS后代的出生测量方面发挥重要作用.
这些发现强调了监测孕妇患有PCOS时甲状腺功能的重要性.

关键词:

在PCOS中,PCOS是PCOS.出生的头部周长出生头部周长出生时间长度出生时间长度出生时的体重出生时的体重.怀孕怀孕怀孕怀孕怀孕甲状腺功能甲状腺功能

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