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便免疫化学测试 (FIT) 灵敏度;五年审计一次.

Eddie Cole1, Deepa Narayanan2, Ree Nee Tiam3

  • 1Blood Sciences Department, York and Scarborough Teaching Hospitals NHS Foundation Trust, York, United Kingdom.

British journal of biomedical science
|June 13, 2024
PubMed
概括

便免疫化学测试 (FIT) 显示了92%的结直肠癌敏感性,但8%的确诊患者有负面结果. COVID-19大流行影响了诊断率,突出了例行查中的潜在假阴性.

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在 COVID-19 疫情中,这就是FITIT.这就是SARS-CoV-2病毒.肠癌是什么意思 肠癌是什么意思结肠直肠癌是什么意思便免疫化学试验我们的肠道是肠道.灵敏度 灵敏度 灵敏度 灵敏度 灵敏度

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科学领域:

  • 胃肠病学 胃肠病学
  • 在瘤学瘤学.
  • 公共卫生 公共卫生

背景情况:

  • 结肠直肠癌 (CRC) 在英国是一个重大的健康负担.
  • 便免疫化学测试 (FIT) 是CRC的主要查工具,检测便中的血红蛋白 (Hb).
  • 了解FIT的现实性能对于早期CRC检测至关重要.

研究的目的:

  • 评估FIT在常规诊断结直肠癌诊断的临床环境中的敏感性.
  • 评估COVID-19大流行对CRC诊断率和FIT表现的影响.
  • 在CRC患者中识别虚假阴性FIT结果的原因.

主要方法:

  • 一个追溯审计的FIT结果和CRC诊断在赫尔和东约克郡 (2018-2022).
  • 对56,202个在有症状的患者身上进行的FIT测试的分析.
  • FIT结果与组织学确认的CRC诊断的相关性.

主要成果:

  • 诊断出1511例CRC病例,450例在12个月内有先前的FIT.
  • FIT灵敏度为92.00%,其中36个 (8.00%) 可能是假阴性结果 (<10μg/g).
  • 改变肠道习惯是最常见的症状促使FIT;COVID-19影响了诊断数字.

结论:

  • 在常规的结直肠癌临床实践中,FIT显示出高灵敏度 (92%).
  • 显著的百分比 (8%) 的CRC患者有负面的FIT结果,表明潜在的假阴性.
  • 该研究强调了COVID-19流行病等外部因素对CRC诊断和查有效性的影响.