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梅丽莎花对癌症患者化疗诱导的外周神经病变的影响:一项随机试验
Zohreh Ehsani1, Ebrahim Salehifar2, Emran Habibi2
1Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
梅丽莎花可能有助于管理化疗诱导的周围神经病变 (CIPN) 的副作用. 这项研究发现,将Melissa officinalis添加到 gabapentin 改善了癌症患者的生活质量,减少了疼痛和腹.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
背景情况:
- 化疗诱导的周围神经病变 (CIPN) 是癌症治疗的常见,令人衰弱的副作用.
- 梅丽莎花 (Melissa officinalis,MO) 含有丰富的黄,具有抗氧化,抗炎和神经保护性质.
- MO可能提供一种补充方法来管理CIPN症状.
研究的目的:
- 评估梅丽莎·奥菲西纳利斯 (Melissa officinalis) 作为CIPN辅助疗法的疗效.
- 评估MO对生活质量和特定CIPN症状的影响.
主要方法:
- 一项随机对照试验,涉及患有CIPN.癌症的癌症患者.
- 干预组接受了 gabapentin 以及 500 mg Melissa officinalis 每天两次,持续 3 个月.
- 对照组接受了 gabapentin 以及安慰剂.
- 患者在基线和3个月后使用CTCAE和EORTC QLQ-C30进行评估.
主要成果:
- 观察到CTCAE最终值的统计学上显著差异 (p=0.010).
- 两组人都在生活质量指标上显著改善.
- 在MO干预组中,疼痛感知和腹的显著减少.
结论:
- 加巴丁与梅丽莎官员结合,改善了CIPN的癌症患者的生活质量指标.
- 在标准化疗方案中添加梅丽莎·奥菲西纳利斯可以缓解与CIPN相关的腹和疼痛.
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