使用系统和定量方法,通过纳米沉产生对PLGA纳米颗粒药物负载的新见解
Sherif I Hamdallah1,2, Randa Zoqlam3, Bin Yang4
1School of Pharmacy, University of East Anglia Norwich NR4 7TJ UK S.hamdallah@uea.ac.uk Sheng.qi@uea.ac.uk.
Nanoscale advances
|June 13, 2024
概括
在PLGA纳米颗粒中的药物载荷通过溶剂系统中的药物溶解度比通过传统参数更好地预测. 这项研究引入了一种新方法来表征药物聚合物相互作用,强调溶解度.
科学领域:
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
- 化学工程是化学工程的重要组成部分.
背景情况:
- 聚乳-同-甘油酸 (PLGA) 纳米颗粒被广泛用于药物输送.
- 目前用于预测PLGA纳米粒子中药物加载效率的方法缺乏精度.
- 现有的预测模型通常依赖于log P和药物聚合物溶解度等参数,这可能是误导性的.
研究的目的:
- 批判性地评估用于PLGA纳米粒子中药物加载的既定方法.
- 提供对毒品捕获机制和预测毒品捕获效率的新见解.
- 研究药物特性和溶剂系统对药物负载的影响.
主要方法:
- 使用纳米沉的PLGA纳米颗粒的合成与四种模型药物 (基托,印米他辛,索拉芬尼,克洛法齐明).
- 使用各种参数评估药物加载效率,包括溶剂/抗溶剂混合物中的溶解度和固态溶解度.
- 引入一个伪常数 (K*) 来描述药物-聚合物相互作用.
主要成果:
- 药物加载效率主要取决于药物在所选择的溶剂系统中的可溶性.
- 动力和热力学因素都会影响药物负载,特别是混合时药物溶解度的变化.
- 虽然伪常数 (K*) 表示药物-聚合物相互作用强度,但药物溶解性是负载能力 (LC) 的关键决定因素.
结论:
- 预测PLGA纳米颗粒中药物负载的既定方法需要改进.
- 药物在溶剂系统中的溶解性是实现高药物载荷能力的关键因素.
- 该研究强调了使用单位来比较不同药物的负载能力的重要性.
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