塞尔托利细胞激素在男性优势中的作用在自闭症谱系障碍中观察到
Şeyda Çelik Göksoy1, Yaşar Tanır1, Nusret Soylu1
1Istanbul University, Istanbul Medical Faculty, Department of Child and Adolescent Psychiatry Istanbul, Turkey.
Noro psikiyatri arsivi
|June 13, 2024
概括
自闭症谱系障碍 (ASD) 显示男性占主导地位. 这项研究在ASD男孩中发现了更高的抑制B (InhB) 水平和更低的2D/4D指数比率,这表明与胎儿丸激素暴露的联系.
科学领域:
- 内分泌学 在内分泌学.
- 神经发育障碍 神经发育障碍
- 儿科 儿科 儿科
背景情况:
- 自闭症谱系障碍 (ASD) 呈现出明显的男性优势,其潜在的生物机制仍然不太清楚.
- 假设胎儿的雄激素暴露在ASD中观察到的性别比率中起作用.
- 激素标记物,如抑制B (InhB) 和抗穆勒尔激素 (AMH),以及2D/4D指比例,是产前雄激素活性的潜在指标.
研究的目的:
- 调查ASD男性占主导地位与InhB和AMH血清水平之间的关联.
- 探索2D/4D手指比率之间的关系,这是胎儿雌激素暴露的标志物,以及ASD.
- 检查这些生物标志物与ASD严重程度之间的潜在相关性.
主要方法:
- 一项病例对照研究包括42名被诊断为ASD的儿童和42名神经类型对照,年龄为5-10岁.
- 用Kiddie-SADS - Present and Life Time (K-SADS PL) 和儿童自闭症评分表 (CARS) 来评估ASD的诊断和严重程度.
- 血清样本分析了InhB和AMH水平,并根据人类测量计算了2D/4D手指长度比.
主要成果:
- 与对照组相比,患有自闭症儿童的血清InhB水平显著更高 (p=0.003).
- 在ASD和对照组之间,血清AMH水平可比.
- 在2D/4D指比率和ASD诊断之间观察到显著的反向关系 (p<0.001),ASD组的比率较低.
- 通过CARS评分 (r=0.315,p=0.05) 测量AMH水平和ASD严重程度之间发现了正相关性.
结论:
- 这些发现表明,InhB,AMH和潜在的胎儿丸激素与在ASD中观察到的男性优势有关.
- 这些荷尔蒙和人体标志物可能提供了对神经发育途径的洞察,这些途径有助于导致ASD流行中的性别差异.
- 需要进一步的研究来阐明这些因素在ASD病因学中的复杂相互作用.
相关概念视频
01:19Autism Spectrum Disorder
80
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
80
02:19The Y Chromosome Determines Maleness
6.6K
The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size....
6.6K
01:26Testosterone: Functions and Regulation
620
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
620
01:41Spermatogenesis
102.4K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.4K
01:43Sex-linked Disorders
102.0K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
102.0K
02:45The Ratio of X Chromosome to Autosomes
8.5K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
8.5K