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苏尔福拉通过调节关键信号通路来促进脂质氧化来增强肌肉生长

Rui Zhang¹, Suqin Chen¹, Feng Zhao²

¹Meat Processing Key Laboratory of Sichuan Province, College of Food and Biological Engineering, Chengdu University, Chengdu, China.

Bioscience reports

|June 13, 2024

概括

硫氨酸 (SFN) 增强肌肉生长并减少小鼠的脂肪. 这项研究表明,SFN可以增加肌肉纤维的大小,并通过影响新陈代谢途径来降低甘油三和胆固醇水平.

科学领域:

营养生物化学营养生物化学
分子生物学分子生物学
运动生理学运动生理学

背景情况:

硫氨酸 (SFN) 是一种在十字花类蔬菜中发现的化合物,具有已知的健康益处.
它对骨肌肉代谢和生长的影响尚未完全理解.

研究的目的:

研究SFN给药对小鼠肌肉生长和脂质代谢的影响.
探索SFN对肌的影响背后的分子机制.

主要方法:

C57BL/6J小鼠接受了两剂SFN (1 mg/kg和3 mg/kg) 的治疗,持续了8周.
分析了体重,肌肉纤维特征 (横截面积,直径) 和长腰 (LD) 肌肉中的脂质含量 (三甘油,总胆固醇).
进行了RNA测序,基因本体学 (GO) 丰富和基因和基因组的京都百科全书 (KEGG) 途径分析.
使用定量实时PCR (qRT-PCR) 验证基因表达变化.

主要成果:

这两种SFN剂量都增加了体重. 更高的剂量 (3mg/kg) 显著增加了LD肌肉纤维大小.
SFN治疗降低了LD肌肉中的甘油三和总胆固醇水平.
RNA测序确定了许多差异表达基因 (DEG),并丰富了GO术语和KEGG通路,特别是与脂质和蛋白质代谢相关的 (例如AMPK,PPAR,mTOR信号传递).
qRT-PCR结果证实了对选定的DEGs的RNA测序数据.

结论:

施用SFN可促进肌肉缩,改善骨肌肉中的脂质概况.
SFN通过调节参与脂质和蛋白质代谢的关键信号通路来发挥作用.
这些发现表明,SFN是肌肉相关疾病和代谢障碍的潜在治疗剂.

关键词:

硫甲是一种硫甲.纤维大小纤维大小纤维大小脂质脂质是什么意思脂质脂质是什么意思代谢过程中的代谢.肌肉生长肌肉生长肌肉生长蛋白质蛋白质是蛋白质蛋白质的组成部分.

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