配方成分和辅助剂类型对difenoconazole可移动的叶片残留物的影响
Mohamed H Badawy1, Darragh Murnane1, Kathleen A Lewis1
1School of Life and Medical Sciences, University of Hertfordshire, Hatfield, Herts, UK.
概括
农药配方显著影响可移除叶残留物 (DFR),影响风险评估. 一种新的实验室方法揭示了配方类型和辅助剂改变了番茄和法式豆类等作物的DFR水平.
科学领域:
- 环境化学环境化学
- 农业科学 农业科学
- 毒理学 毒理学 毒理学
背景情况:
- 农药风险评估需要准确的可移动叶残留物 (DFR) 数据,以符合监管要求.
- 由于对影响因素的了解不足,DFR研究受到成本,季节性和监管机构不愿意推断数据的限制.
- 杀虫剂配方是可能影响DFR的关键因素,但其影响尚未得到充分描述.
研究的目的:
- 用一种新型实验室方法研究农药配方对可移除叶残留物 (DFR) 的影响.
- 评估不同的农药配方 (乳化缩剂与可湿粉) 和辅助剂如何影响各种作物的DFR.
主要方法:
- 使用了一种新的实验室DFR方法.
- 活性物质difenoconazole作为可乳化缩物 (EC 10%) 和可浸泡粉末 (WP 10%) 进行了测试.
- 对番茄,法式豆类和油菜进行了测试,有或没有辅助剂 (Tween 20,TEHP).
主要成果:
- 大多数作物的WP和EC配方中保留了可比的DFR百分比.
- 与EC (60%) 相比,西红与WP (39%) 的DFR%显着较低.
- 辅助剂的添加一般没有显著的影响,除了TEHP与EC在法国豆,减少DFR8%.
结论:
- 农药配方是影响DFR水平的一个重要因素.
- 开发的实验室DFR技术对于评估配方和辅助剂影响是有价值的.
- 调查结果有助于完善对农药暴露的风险评估和监管方法.
相关概念视频
Factors Affecting Dissolution: Particle Size and Effective Surface Area
800
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
800
Factors Influencing Drug Absorption: Pharmaceutical Parameters
129
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
129
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
295
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
295
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry
196
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
196
Colloidal precipitates
560
The high insolubility of some precipitates can result in an unfavorable relative supersaturation. This can lead to colloidal particles with a large surface-to-mass ratio, where adsorption is promoted. For instance, in the precipitation of silver chloride, silver ions are adsorbed on the surface of the colloidal particles, forming a primary layer. This layer attracts ions of opposite charge (such as nitrate ions), forming a diffuse secondary layer of adsorbed ions. This electric double layer...
560
Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model
286
Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
286


