PD-L1通过代谢转移促进瘤性病毒感染,抑制I型IFN通路

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Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction
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Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

Published on: July 7, 2023

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Jonathan J Hodgins1,2,3, John Abou-Hamad1,4, Colin Edward O'Dwyer1,2,3

  • 1Cancer Therapeutics Program, Ottawa Hospital Research Institute , Ottawa, Canada.

The Journal of experimental medicine
|June 13, 2024
PubMed
概括

编程死亡配体1 (PD-L1) 具有内在功能,抑制癌细胞I型干扰素反应. 这种抑制增强了型病毒的疗效,提出了新的治疗策略.

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