纳入的药物会影响水友纳米纤维的特性
Črt Dragar1, Robert Roškar2, Petra Kocbek1
1Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ljubljana, SI-1000 Ljubljana, Slovenia.
Nanomaterials (Basel, Switzerland)
|June 13, 2024
概括
药物特性显著影响水性纳米纤维用于药物输送,影响溶液特性和纳米纤维形态. 然而,药物加载,捕获和立即释放仍然是一致的,突出显示了聚合物的主导地位.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 制药科学 制药科学
背景情况:
- 水性纳米纤维显示出对各种药物输送应用的前景.
- 了解合并药物如何影响纳米纤维特性至关重要,但人们对其了解甚少.
研究的目的:
- 为了研究模型药物 (易布洛芬,卡维迪醇,,甲胺) 对水友纳米纤维 (聚乙烯氧化物/poloxamer 188) 的影响.
- 探索药物的物理化学特性如何影响电和纳米纤维特性.
主要方法:
- 在水性纳米纤维中系统地探索四种模型药物.
- 聚合物溶液特性 (导电性,粘度) 和电纳米纤维形态的分析.
- 对药物加载,捕获效率和立即释放药物的评估.
主要成果:
- 药物特性影响了聚合物溶液的导电性和粘度,改变了纳米纤维形态.
- 在乙醇中药物的低溶解性导致均的纳米纤维; 甲胺的溶解性导致表面颗粒.
- 增加的药物水友性增强了纳米纤维表面的水友性,而加载和释放仍然不受影响.
结论:
- 药物溶解性和水友性对于设计用于药物输送的水友性纳米纤维至关重要.
- 水友性聚合物在很大程度上决定了药物加载,捕获和即时释放动力学.
- 仔细考虑药物溶剂相互作用对于优化药物输送系统至关重要.
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