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针对低度严重卵巢癌的向治疗方法

Anna Gonzalez¹, Christa I Nagel², Paulina J Haight¹

¹Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The Ohio State University Wexner Medical Center, James Hospital and Solove Research Institute, M-210 Starling Loving Hall, 320 W. 10th Avenue, Columbus, OH, 43210, USA.

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概括

低等级的卵巢癌与高等级的卵巢癌不同. 虽然手术是关键,激素治疗是有效的,而新的向疗法对复发性疾病有希望.

科学领域:

妇科瘤学妇科瘤学
分子病理学分子病理学
翻译医学是一种翻译医学.

背景情况:

卵巢的低级血清性癌 (LGSC) 现在被认为是一个与高级血清性癌 (HGSC) 不同的临床病理实体.
分子分析使LGSC的理解更深入,揭示了特定的途径和潜在的治疗点.
对于卵巢癌的传统治疗模式需要在LGSC独特的生物学背景下重新评估.

研究的目的:

将LGSC与HGSC相比的独特特征划分出来.
审查目前和新兴的LGSC治疗策略,包括初级和经常性设置.
突出分子变化的作用,以指导LGSC的治疗决策.

主要方法:

对LGSC当前文献的审查,包括分子分析研究和临床试验数据.
分析手术和化疗在LGSC管理中的确定的作用.
在LGSC中对激素治疗和新型向药物 (MEK,CDK4/6,PI3KCA抑制剂) 的评估.

主要成果:

LGSC 具有与 HGSC 截然不同的分子特征,影响治疗反应.
手术仍然是初级和复发性LGSC的关键组成部分.
激素疗法在LGSC中显示出高响应率和耐受性.
针对性治疗正在成为LGSC复发的有希望的选择.

结论:

对于LGSC来说,它需要与HGSC不同的定制管理策略.
荷尔蒙疗法是LGSC的一个有价值的治疗选择.
针对性治疗和正在进行的临床试验为基于分子生物标志物的LGSC提供了未来的治疗途径.

关键词:

低度的血清卵巢癌是低度的卵巢癌.

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