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类风湿性关节炎和慢性牙周炎之间的相关性:系统性审查和元分析
Deepika Rak1, Anita M Kulloli1, Sharath K Shetty1
1Department of Periodontology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, India.
Minerva dental and oral science
|June 13, 2024
概括
这项研究表明,类风湿性关节炎 (RA) 和牙周病之间存在联系,并指出临床附着水平,牙损失和探针深度的关联. 需要进一步的大规模研究来证实这种联系.
科学领域:
- 口腔健康 口腔健康
- 类风湿病学 类风湿病学
- 系统性炎症 系统性炎症
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病.
- 牙周炎是一种常见的炎症状况,影响牙和牙的支结构.
- 人们假设RA和牙周炎之间存在潜在的联系.
研究的目的:
- 总结,比较和评估牙周炎和类风湿性关节炎之间的关联.
- 评估现有的关于这两个条件之间的关系的定量研究.
主要方法:
- 针对2000年至2022年12月期间发表的研究,在三个库中进行了系统的文献搜索.
- 包含的研究的质量评估是使用纽卡斯尔-太华尺度 (NOS) 进行的.
- 使用随机效应模型的元分析被用来计算各种参数的标准化平均差异 (SMD).
主要成果:
- 包含了14篇论文,其中13篇符合元分析的条件.
- 在临床附着水平 (SMD=0.68),牙损失 (SMD=1.62) 和探针深度 (SMD=0.53) 中,在RA和牙周炎之间发现了显著的关联.
- 对斑块指数的聚合估计也表明了潜在的联系 (SMD=0.29),没有发现显著的系统异质性.
结论:
- 这些发现表明牙周病和类风湿性关节炎之间存在联系.
- 建议进行更大规模的基于人口的调查来验证这一关联.
- 未来的研究应该专注于严格的病例控制研究,以精确定义的群体和初级临床结果.
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