在化疗后患有急性髓性白血病的老年人中,家庭时间
Daniel R Richardson1,2, Xi Zhou2, Katherine Reeder-Hayes1,2
1University of North Carolina School of Medicine, Chapel Hill.
JAMA oncology
|June 13, 2024
概括
患有急性髓性白血病 (AML) 的老年人在家用低甲基化剂 (HMA) 度过的时间超过了与人环素治疗的时间. 尽管人环素的生存时间更长,但住院次增加抵消了这一好处,减少了回家的时间.
科学领域:
- 老年瘤学 老年瘤学
- 血液学恶性瘤是什么
- 医疗保健服务研究 医疗服务研究
背景情况:
- 患者对家居时间的偏好在急性髓性白血病 (AML) 治疗决策中至关重要.
- 关于AML的老年人家庭时间的数据有限.
研究的目的:
- 量化和比较老年人 (≥66岁) 患有AML的家庭时间.
- 为了评估基于人环素的化疗和低甲基化剂 (HMAs) 之间的家庭时间差异.
主要方法:
- 使用SEER-Medicare数据 (2004-2016) 的回顾性队列研究.
- 包括7946名新诊断AML的老年人.
- 家庭时间计算为幸存的天减去设施中的天,除以幸存的天总数.
- 调整后的分析使用了治疗权重的稳定反向概率.
主要成果:
- 第一年调整后的家庭时间总体为52.4%.
- 在HMA (60.8%) 的家庭时间比在Anthracycline (51.9%) 的家庭时间更高.
- 服用HMA的患者比服用Anthracycline的患者在家的总日数更多,并且在第一年多33天.
结论:
- 对于患有AML的老年人来说,由于增加了医疗机构的入院,反环素治疗的生存益处可能会被否定.
- 在老年AML患者中,HMA似乎促进了更多的家庭时间.
- 老年AML患者的治疗选择应考虑对生活质量的影响,包括家庭时间.
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