种族歧视,神经连接和黑人女性表观遗传衰老
Aziz Elbasheir1, Seyma Katrinli1, Breanne E Kearney2,3
1Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.
JAMA network open
|June 13, 2024
概括
种族歧视与黑人女性的加速衰老和改变大脑连接性有关. 部 (LC) 和前部的这些变化可能会增加对大脑健康问题的脆弱性.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 种族歧视是已知的压力因素,与不良的大脑健康结果有关.
- 深层大脑区域在这些反应中的作用和与表观遗传衰老的联系尚不清楚.
研究的目的:
- 研究黑人女性的种族歧视,脑干和中脑静止状态功能连接 (RSFC) 和DNA甲基化年龄加速 (DMAA) 之间的关联.
主要方法:
- 一项对90名黑人女性的队列研究检查了自我报告的种族歧视.
- 休息状态功能连接性 (RSFC) 分析使用局部coeruleus (LC) 种子.
- 用全血样评估了DNA甲基化年龄加速 (DMAA).
主要成果:
- 较大的种族歧视与增加的LC与先性RSFC相关.
- 这种改变的连接间接地将种族歧视与DMAA联系起来.
结论:
- 种族歧视可能会通过改变LC-precuneus连接来加速生物衰老.
- 这些发现突出了一个潜在的机制,增加了对大脑健康问题的脆弱性.
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