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Updated: Jun 24, 2025

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
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单氨酸氧化酶-A (MAO-A) 低表达变体和增加Plasmodium vivax疟疾复发的风险

Maria Carolina Silva De Barros Puça1, Danielle Fonseca Rodrigues1, Yanka Evellyn Alves Rodrigues Salazar1

  • 1Molecular Biology and Malaria Immunology Research Group, Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ), Belo Horizonte, Minas Gerais, Brazil.

The Journal of antimicrobial chemotherapy
|June 13, 2024
PubMed
概括

单氨酸氧化酶-A (MAO-A) 和CYP2D6酶的遗传变异会影响普莱马奎因的新陈代谢,增加Plasmodium vivax疟疾复发. 低MAO-A活性与受损的CYP2D6功能相结合,显著降低了卡西普里马奎因水平,导致治疗失败.

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