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Updated: Jun 24, 2025

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在患有上腺皮层腺瘤的患者中,高的LDL粒子和APOB度
Rashi Sandooja1, Jasmine Saini1, Annop Kittithaworn1
1Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA.
The Journal of clinical endocrinology and metabolism
|June 13, 2024
概括
患有上腺瘤的患者,即使没有明显的皮质醇过量,也表现出异常的脂蛋白样本,包括升高的低密度脂蛋白颗粒 (LDLP) 和无脂蛋白B (ApoB),增加心血管风险.
科学领域:
- 内分泌学和新陈代谢学
- 评估心血管风险评估
- 利皮多米克 (Lipidomics) 是一种消化剂.
背景情况:
- 患有非功能性腺瘤 (NFAs),轻度自主皮质醇分泌 (MACS) 和库辛综合征 (CS) 的患者心血管风险增加.
- 了解潜在的脂蛋白异常对于管理这些患者群体的心脏代谢风险至关重要.
研究的目的:
- 调查和量化患有NFA,MACS和CS的患者的脂蛋白异常.
- 为了比较这些疾病中的脂蛋白样本,并与参考组进行比较.
主要方法:
- 一个单中心的横截面研究包括167名NFA,213名MACS,142名CS患者和202名参考个人.
- 核磁共振光谱法用于测量富含甘油三脂脂蛋白颗粒 (TRLP),低密度脂蛋白颗粒 (LDLP),高密度脂蛋白颗粒 (HDLP),它们的子类和大小.
- 多变量后勤分析被调整为关键的心血管风险因素和降脂药物治疗.
主要成果:
- 所有患者群体的TRLP和LDLP度都增加了,并且与参考组相比,即使在完全调整后,粒子大小也发生了变化.
- 在所有患者类别中观察到总胆固醇,LDL胆固醇,甘油三和阿波蛋白B (ApoB) 的升高.
- 脂蛋白异常,特别是高的LDLP和ApoB,即使在排除接受降脂治疗的患者时也持续存在.
结论:
- 皮质醇过量,无论是明显的,轻微的还是不存在的,都与显著的脂蛋白特征异常有关.
- 增加的LDLP和ApoB度是NFA,MACS和CS患者的关键发现.
- 这些脂蛋白异常可能有助于在这些条件下观察到的心脏代谢风险增加.
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