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Updated: Jun 24, 2025

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通过双链体固相合成高纯度DNA编码的化学库

Michelle Keller1, Dimitar Petrov1, Andreas Gloger1

  • 1Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland.

Science (New York, N.Y.)
|June 13, 2024
PubMed
概括

用DNA编码的化学库 (DEL) 提供了一种强大的药物发现方法. 这项研究引入了一种自净化的DEL合成技术,以提高化合物的纯度和提高选择性能.

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DNA isolation protocols can be fast and straightforward or complex and time-consuming depending on the type and quality of DNA required for further processing. For example, plasmid DNA extraction is a bit more complicated than genomic DNA extraction because of the need for an appropriate lysis method to separate plasmid DNA from gDNA during isolation. However, for specific applications, such as long-range DNA sequencing that require a good yield of high- quality DNA samples, we need to follow...
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