相关实验视频
Updated: Jun 24, 2025

09:26
Quantification of Orofacial Phenotypes in Xenopus
Published on: November 6, 2014
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裂唇侧面性和与其他先天性形相关的相关性
Matthew Fell1,2, Kate J Fitzsimons3, Mark J Hamilton4
1Spires Cleft Centre, John Radcliffe Hospital, Oxford, UK.
概括
在裂口 +/- 膜 (CL +/- A) 病例中,额外的先天性形的患病率与裂口侧面没有差异. 然而,与左侧CLP相比,右侧和双边裂口唇 (CLP) 病例的额外异常率较高.
科学领域:
- 医学研究 医学研究
- 遗传学 是一个遗传学.
- 儿科 儿科 儿科
背景情况:
- 面腔裂是常见的出生缺陷.
- 裂的侧面性 (左侧,右侧或双侧) 可能与其他先天性异常有关.
- 了解这些关联可以提供关于潜在病因学的见解.
研究的目的:
- 调查 orofacial 裂的侧面性与其他先天性形的发生之间的关联.
- 为了比较左侧,右侧和双侧裂唇 +/- 膜 (CL +/- A) 和裂唇和 palatal (CLP) 现型中相关异常的患病率.
主要方法:
- 利用了国家裂口出生登记处与英国国家医院入院数据的联系.
- 分析了2007年CL +/- A的儿童和2000年至2012年间出生的CLP的2724名儿童的数据.
- 确定了基于裂侧的额外先天性形的ICD-10代码的儿童比例.
主要成果:
- 对于CL +/- A,在左 (22%),右 (22%),双边 (23%) 裂之间没有发现额外形患病率的显著差异.
- 对于CLP,与右侧 (32%) 和双边 (33%) 裂相比,左侧裂 (23%) 的额外形患病率较低.
- 统计分析显示了CLP的显著差异 (P<0.001对右侧和双侧与左侧).
结论:
- 额外的先天性形的患病率在CLP病例中因侧面性而异,但在CL +/- A病例中不同.
- 研究结果表明,CL +/- A和CLP的潜在病因是不同的.
- 右侧CLP的病因可能与双边CLP比左侧CLP更相似.
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