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Updated: Jun 24, 2025

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热容量效应在蛋白质-连接物结合中的计算分析

Lucien Koenekoop1, Johan Åqvist1

  • 1Department of Cell & Molecular Biology, Uppsala University, Biomedical Center, SE-751 24 Uppsala, Sweden.

Journal of chemical theory and computation
|June 13, 2024
PubMed
概括

计算机模拟准确地预测了蛋白质 - 配体结合中的热容量变化. 这一发现对于优化酶抑制剂至关重要,因为它了解了结合度的温度依赖性.

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