相关实验视频
Updated: Jun 24, 2025

12:00
A Practical Guide to Phylogenetics for Nonexperts
Published on: February 5, 2014
35.3K
将DEPP的基因组定位扩展到超大参考树:一种树意识的集体方法
Yueyu Jiang1, Daniel McDonald2, Daniela Perry2
1Electrical and Computer Engineering Department, University of California San Diego, 9500 Gilman Dr, La Jolla, CA, 92093, United States.
Bioinformatics (Oxford, England)
|June 13, 2024
概括
一种新的方法,C-DEPP,使用分裂与征服来实现对大物种树木的精确基因排序. 这种方法扩展了机器学习,以有效地分析数百万个DNA序列.
科学领域:
- 生物信息学是一种生物信息学.
- 计算生物学 计算生物学
- 机器学习 机器学习
背景情况:
- 基因组系对DNA序列的定位对于生物医学科学中的样本鉴定至关重要.
- 随着参考树的规模不断增加,当前的方法难以扩展,限制了对大型数据集的分析.
- 使用度量学习的DEPP方法,由于二次距离矩阵计算,面临着大规模的家族遗传树的计算挑战.
研究的目的:
- 开发一种可扩展的方法,用于在非常大的物种树上进行遗传学定位.
- 为了克服现有的度量学习方法 (如DEPP) 的计算局限性.
- 为了能够准确地分析数以百万计的序列在广泛的参考族系.
主要方法:
- 探索用于培训DEPP模型组合的分裂与征服策略.
- 开发C-DEPP (分片DEPP) 方法,其中包含准线性缩放的专业技术.
- 将C-DEPP应用于大规模的遗传学数据集,包括Greengenes2参考树.
主要成果:
- C-DEPP实现了近线性扩展,克服了传统的二次学习的复杂性.
- 该方法成功地扩展到含有数十万种物种的参考树.
- 在41小时内,C-DEPP能够将2000万个16S碎片放置在Greengenes2树上.
结论:
- C-DEPP提供了一种计算效率高,准确的解决方案,用于大规模的基因排序.
- 开发的方法显著提高了标记基因和全基因组数据分析的可扩展性.
- 自由可用的软件和数据集促进了更广泛的采用和进一步的研究.
相关概念视频
Evolutionary Relationships through Genome Comparisons
5.7K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
5.7K
Phylogenetic Trees
45.3K
Phylogenetic trees come in many forms. It matters in which sequence the organisms are arranged from the bottom to the top of the tree, but the branches can rotate at their nodes without altering the information. The lines connecting individual nodes can be straight, angled, or even curved.
45.3K
Survival Tree
79
Survival trees are a non-parametric method used in survival analysis to model the relationship between a set of covariates and the time until an event of interest occurs, often referred to as the "time-to-event" or "survival time." This method is particularly useful when dealing with censored data, where the event has not occurred for some individuals by the end of the study period, or when the exact time of the event is unknown.
Building a Survival Tree
Constructing a...
Building a Survival Tree
Constructing a...
79
Phylogeny
43.8K
Phylogeny is concerned with the evolutionary diversification of organisms or groups of organisms. A group of organisms with a name is called a taxon (singular). Taxa (plural) can span different levels of the evolutionary hierarchy. For instance, the group containing all birds is a taxon (comprising the class Aves), and the group of all species of daisies (the genus Bellis) is a taxon. Phylogenies can likewise include just one genus (i.e., depict species relationships) or span an entire kingdom.
43.8K
The Tree of Life - Bacteria, Archaea, Eukaryotes
32.3K
The “tree of life” describes the evolution of life and the evolutionary relationships between organisms. The root of the tree is the common ancestor to all life on Earth. All other species radiate from this point, much like the branches of a tree. The numerous tips of these branches on the tree of life represent every living, or extant, species. Extinct species, which are species that no longer exist, can be found towards the center of the tree. Currently, these organisms, both...
32.3K
Genome Annotation and Assembly
18.8K
The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
18.8K

