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使用分子动力学模拟识别心脏L型通道和calmodulin之间的关键结合相互作用

D'Artagnan Greene1, Yohannes Shiferaw1

  • 1Department of Physics and Astronomy, California State University Northridge, 18111 Nordhoff Street, Northridge, California 91330-8268, United States of America.

The journal of physical chemistry. B
|June 13, 2024
PubMed
概括

卡尔莫杜林 (CaM) 与心脏通道结合的缺陷会导致心律失常. 这项研究揭示了CaV1.2和RyR2的明显的CaM结合模式,解释了突变如何导致长QT综合征或CPVT.

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