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Updated: Jun 24, 2025

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
09:45

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

Published on: April 27, 2017

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一个小分子降解与一个烯酸酸支架降解

Shusuke Tomoshige1, Fumiko Komatsu2, Tomoko Kikuchi3

  • 1Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, 2641 Yamazaki, Noda, Chiba 278-8510, Japan; Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.

Bioorganic & medicinal chemistry
|June 13, 2024
PubMed
概括

研究人员发现了一种新的小分子降解子,用于向蛋白质降解 (TPD),使用向蛋白质溶解的嵌合体 (PROTAC). 这种来自S相激酶相互作用蛋白2 (Skp2) 连接体的新型降解子,通过无素-蛋白酶系统 (UPS) 有效降解标蛋白质.

关键词:
烯基烯酸是一种烯酸.小分子降解的降解有针对性的蛋白质降解降解.

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