聚环芳的对肠轴的影响
Yuanjie Li1, Haitao Ma1, Junling Wang1
1Department of Toxicology, School of Public Health, Lanzhou University, Lanzhou 730000, China.
Ecotoxicology and environmental safety
|June 13, 2024
概括
多环芳 (PAH) 破坏肠道微生物群,可能损害男性生殖功能. 本综述探讨了PAH与肠道微生物的相互作用及其对肠-丸轴的影响.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 微生物学 微生物学
背景情况:
- 多环芳 (PAH) 是广泛存在的环境污染物.
- 众所周知,PAHs具有致癌性和致变性毒性.
- 多氧化对肠丸轴的影响仍然未得到充分探索.
研究的目的:
- 审查PAHs和肠道微生物群之间的相互作用.
- 总结导致肠道微生物群失调的不良结果.
- 阐明肠道失生症损害男性生殖功能的机制.
主要方法:
- 文献综述侧重于PAH与微生物群的相互作用.
- 综合关于肠道失生症和男性生殖健康的研究.
- 分析连接PAHs,肠道微生物群和肠-试管轴的机制性途径.
主要成果:
- 氧化与肠道微生物群相互作用,可能导致失活性.
- 肠道微生物群失调与男性生殖功能受损有关.
- 通过肠道微生物群,为PAH诱导的生殖毒性提出了特定的机制途径.
结论:
- 由于肠道微生物群的破坏,PAHs对男性生殖健康构成风险.
- 了解这些机制对于风险评估和降低风险至关重要.
- 需要进一步的研究,以充分阐明肠-试管轴的相互作用.
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