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环保的化碳量子点用于在药品囊中测定普雷加巴林的光谱度测定
Mohamed Ahmed Abdel Hamid1, Samar H Elagamy2, Aya Gamal2
1Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Tanta University, Tanta 31111, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al Salam University, Tanta, Egypt.
Journal of pharmaceutical and biomedical analysis
|June 13, 2024
概括
一种新的环保方法使用化碳量子点 (CQD) 进行敏感的普雷加巴林检测. 这种快速,选择性的计方法为制药分析提供了更绿色的替代方案.
科学领域:
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
背景情况:
- 预加巴林的滥用需要敏感和选择性的确定方法.
- 现有的方法可能缺乏环境可持续性或效率.
研究的目的:
- 开发一种环保,高度敏感和选择性的度测量方法来确定普雷加巴林.
- 为了利用新型的化碳量子点 (Co-NS-CQDs) 作为纳米探测器.
主要方法:
- 使用快速微波辅助方法合成混合化 (,硫,) 碳量子点 (Co-NS-CQDs).
- 采用Co-NS-CQD作为纳米探针以基于光增强的普雷加巴林的度测定.
- 在药品囊中验证了pregabalin的方法.
主要成果:
- 同-NS-CQDs表现出高量子产率 (55%) 和蓝色辐射 (438 nm).
- 该方法显示出良好的线性 (25-250μg/mL),低检测极限 (4.17μg/mL) 和量化极限 (12.63μg/mL).
- 在药品囊分析中获得了很好的恢复 (98-102%).
结论:
- 开发的Co-NS-CQD提供了一个快速,灵敏,选择性和环保的平台来确定普雷加巴林.
- 这种方法为传统技术 (如RP HPLC) 提供了更绿色的替代方案.
- 这种方法适合在真实制药样本中对普雷加巴林进行量化.
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