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Updated: Jun 24, 2025

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宿主压力驱动耐受性和持久性:抗微生物疗法的祸害

Sophie Helaine1, Brian P Conlon2, Kimberly M Davis3

  • 1Department of Microbiology, Harvard Medical School, Boston, MA, USA.

Cell host & microbe
|June 13, 2024
PubMed
概括

抗生素回收,一种短暂的细菌生存策略,延长了治疗失败的时间. 了解这些持久且耐受性细菌种群是开发针对具有挑战性的感染的新疗法的关键.

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Defense Against Bacterial Pathogens

The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
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