出生方式和环境依赖的微生物群传播动态在第一年内被母乳养补充
Marta Selma-Royo1, Léonard Dubois2, Serena Manara2
1Institute of Agrochemistry and Food Technology-Spanish National Research Council (IATA-CSIC), Paterna, Valencia, Spain; Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
Cell host & microbe
|June 13, 2024
概括
出生环境和分娩方式影响婴儿肠道微生物群的传播. 母乳养会影响Bifidobacterium longum等特定物种,影响它们的母乳寡糖体 (HMO) 降解能力.
科学领域:
- 微生物学 微生物学
- 人类微生物组 人类微生物组
- 婴儿健康 婴儿健康
背景情况:
- 生命早期的微生物群发育对于婴儿健康至关重要.
- 围产期因素显著影响微生物殖民.
- 生育环境和垂直传播之间的相互作用需要进一步阐明.
研究的目的:
- 为了研究母婴微生物群在不同出生环境中的传播.
- 了解分娩方式和出生地点对传播动态的影响.
- 分析菌株水平的变化及其与婴儿养实践的关联.
主要方法:
- 使用先进的菌株追踪方法.
- 在医院出生的 (阴道/剖腹产) 和在家出生的 (阴道) 婴儿及其母亲中比较微生物群传播.
- 对Bifidobacterium longum进行了菌株水平分析.
主要成果:
- 生产方式决定了最初的微生物群组成,而出生地点影响了传播时间 (家庭分娩的早期,剖腹产的延迟).
- 包括Bifidobacterium longum在内的某些物种,在各种环境中显示出一致的垂直传播.
- 哺乳实践推动Bifidobacterium longum的亚种替代,影响人乳寡糖化物 (HMO) 降解能力.
结论:
- 产生的环境,母乳养和生活方式共同塑造了婴儿肠道殖民.
- 了解这些因素是优化早期微生物发育的关键.
- 应变水平分析为婴儿肠道中的微生物适应和功能提供了关键的见解.
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