试图忘记酒精:大脑机制是年轻暴饮酒者内存抑制的基础
Natália Almeida-Antunes1, Luis Antón-Toro2, Alberto Crego1
1Psychological Neuroscience Laboratory (PNL), Psychology Research Center (CIPsi), School of Psychology, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.
概括
过度饮酒者由于大脑连接受损,难以忘记非酒精记忆. 然而,它们在抑制酒精记忆时显示大脑活动升高,可能弥补缺陷.
科学领域:
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
- 成研究 研究成研究
背景情况:
- 记忆抑制是一种认知能力,允许自愿忘记不需要的想法.
- 过度饮酒 (BD) 与抑制控制 (IC) 的受损以及酒精-cue反应能力的提高有关.
- 在BD中抑制与酒精有关的记忆的能力仍然未经检查.
研究的目的:
- 研究年轻暴饮酒者 (BDs) 记忆抑制的行为和神经功能机制.
- 评估记忆抑制能力,特别是BD中与酒精有关的线索.
- 探索抑制控制 (IC) 和记忆网络之间的功能连接 (FC) 模式.
主要方法:
- 82名大学生 (40名非/低饮酒者[N/LDS],42名BD),年龄在18-24岁之间,完成了"思考/不思考酒精"任务.
- 脑电图 (EEG) 在压抑记忆的任务中记录了大脑活动.
- 基于种子的动态分析计算了IC和内存网络之间的功能连接 (FC) 的相锁定值.
主要成果:
- 与N/LD相比,BDs显示阿尔法频段FC (前带皮质-左状) 减少,并且无法忘记非酒精记忆.
- 在酒精记忆抑制期间,BDs表现出加大的马波段FC (IC网络-海马体,甲海马体,状圈).
- 这些发现表明BDs的抑制缺陷,在酒精记忆抑制期间的超连接性可能会补偿对突出线索的注意.
结论:
- 在BD中抑制性控制缺陷可能表现为非酒精记忆的低连接性.
- 在抑制酒精记忆时,BDs表现出超连接性,可能是由于注意力和补偿机制的增加.
- 研究结果表明,新的治疗目标主要是加强对与酒精有关的记忆的控制,以减少酒精使用.
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