在听觉注意力和工作记忆任务期间,在人类中枢中核中调节神经元活动
Frhan I Alanazi1, Carlos Aníbal Restrepo Bravo2, Juan Sebastián Saavedra Moreno3
1Department of Physiology, University of Toronto, Canada; Krembil Brain Institute, Leonard St, Toronto Ontario, Canada; Department of Basic Sciences, Prince Sultan bin Abdulaziz College for Emergency Medical Services, King Saud University, Riyadh, Kingdom of Saudi Arabia.
NeuroImage
|June 13, 2024
概括
中介核 (CM) 在听觉注意力和工作记忆中起着关键作用. CM神经元对偏差音调表现出选择性的反应,β和低马振荡支持认知过程.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
背景情况:
- 中心中间核 (CM) 是一个内层的胸膜内核,与意识,兴奋和注意力有关.
- 虽然动物模型已经探索了注意力神经生理学,但在CM中结合单单元和局部现场潜力 (LFP) 记录的人类研究缺乏.
研究的目的:
- 通过使用人类记录来研究CM核在听觉注意力和工作记忆中的作用.
- 在听觉注意力任务期间检查CM中的神经元发射率和LFP振荡.
主要方法:
- 在11名患者中,从CM核记录了神经元活动,这些患者接受了深度前脑刺激手术.
- 患者执行了一个听觉注意力任务,包括区分罕见的偏差音调和频繁的标准音调.
- 进行了尖峰区分和LFP带通选 (5-45 Hz),随后进行了周周刺激时间组图和光谱分析.
主要成果:
- 81%的CM神经元表现出对偏差音的选择性,多相发射速率反应.
- 在LFPs显示选择性β和低马 (13-45 Hz) 调制响应偏差音调,也在多相模式.
- 这些发现表明,在选择性听觉处理过程中,CM神经元的自上而下的控制.
结论:
- CM核参与选择性听觉注意力和工作记忆.
- 在CM中β和低马振荡活动支持认知过程.
- 结果对的深度大脑刺激 (DBS) 疗法和帕金森病中的冷漠性等非运动症状有影响.
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