肠道微生物组和血代谢组的甲胺诱导的变化与男性的认知有关
Marisel Rosell-Díaz1, Anna Petit-Gay2, Clàudia Molas-Prat2
1Department of Diabetes, Endocrinology and Nutrition, Dr. Josep Trueta University Hospital, Girona, Spain; Nutrition, Eumetabolism and Health Group, Girona Biomedical Research Institute (IDIBGI-CERCA), Girona, Spain and University of Girona, Girona, Spain; CIBER Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain.
Metabolism: clinical and experimental
|June 13, 2024
概括
在2型糖尿病 (T2D) 中使用甲胺会改变肠道细菌,可能改善认知能力,特别是在男性中. 这种药物影响微生物通路和代谢物,表明肠道健康和大脑功能之间存在联系.
科学领域:
- 微生物组研究的研究.
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 2型糖尿病 (T2D) 与肠道失调,减少酸盐生产者和认知能力下降有关.
- 一种T2D药物梅特福林与降低痴呆风险和提高认知能力有关.
研究的目的:
- 为了调查甲胺与认知的关联.
- 通过肠道微生物组和血代谢组分析来探索机制.
主要方法:
- 分析了两个独立的队列 (衰老图像学,MEIFLO) 与四个研究小组.
- 射击枪元基因组学和HPLC-ESI-MS/MS用于微生物组和代谢组的分析.
- 按性别分层分析.
主要成果:
- 甲胺与蛋白质细菌 (大肠杆菌) 和微型细菌 (A. muciniphila) 的增加,以及Firmicutes (R. timonensis,R. ilealis) 的减少有关.
- A. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/A. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. muciniphila/R. 在二型糖尿病患者接受甲福林治疗的男性中,阴茎与记忆的比率与记忆有关.
- 甲胺丰富了微生物通路 (TCA循环,丁酸盐,氨酸,氨酸,氨酸代谢) 和谷氨酸生产基因,与氨酸水平相关联.
结论:
- 甲胺的认知益处可能源于肠道微生物群的转变.
- 微生物和宿主衍生的共同代谢物是甲福林作用的潜在媒介.
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