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Shiping Ding¹, Jiangtao Zhou¹, Junlong Xiong¹

¹State Key Laboratory for Animal Disease Control and Prevention, South China Agricultural University, Guangzhou, 510642, China; National Avian Influenza Para-Reference Laboratory, Guangzhou, 510642, China; Key Laboratory of Zoonoses, Ministry of Agriculture and Rural Affairs, Guangzhou, 510642, China; National and Regional Joint Engineering Laboratory for Medicament of Zoonoses Prevention and Control, Guangzhou, 510642, China.

Virologica Sinica

|June 13, 2024

概括

在中国,新的禽流感病毒 (AIV) H10N3菌株显示出增加的稳定性和人类传播的潜力. 持续监测对于防止未来的流行病至关重要.

科学领域:

病毒学病毒学
公共卫生公共卫生
分子流行病学分子流行病学

背景情况:

禽流感病毒 (AIV) H10亚型对禽类和人类健康构成重大威胁.
致命的人类感染H10N3和H10N8引起了公众健康的担忧.
H9N2病毒在家禽中是特有的,并有助于AIV的演变.

研究的目的:

来自中国的新分离的H10N3 AIV菌株的特征.
为了比较H10N3和H10N8AIVs的生物特性.
在小鼠模型中评估这些病毒的致病潜力.

主要方法:

从患病的中分离并对H10N3 AIVs进行全基因组测序.
遗传学分析以确定遗传起源.
在体外测试以评估热稳定性和病毒释放.
在小鼠模型中进行致病性研究.

主要成果:

2022年在中国分离的两种H10N3 AIV与人类起源的H10N3病毒有遗传联系,其内部基因来自当地H9N2病毒.
与H10N8.8相比,H10N3病毒表现出增强的热稳定性和血凝素 (HA) 蛋白积累.
H10N3病毒感染了小鼠的肺和鼻,而H10N8病毒感染了肺和大脑.
自2019年以来,在H10N3病毒中观察到双HA突变 (Q222R和G228S) 的流行率增加.

结论:

由于其与人类菌株的遗传联系和改变的生物特性,H10N3 AIV构成潜在的公共卫生风险.
在HA中观察到的突变可能会影响病毒的致病性和传染性.
持续监测H10N3的演变对于疫情的准备和控制至关重要.

关键词:

禽流感病毒 (AIV) 是一种禽流感病毒.进化进化进化进化进化进化进化 H10N3 H10N3 H10N3 H10N3 H10N3 H10N3 H10N3 H10N3 H10N3 H10N3 H10N3 H10N3 H10N3 H10N3 H10N3 H10N3 H10N3 H10N3 H10N3 H10N3 H10N3 H10N3 H10N3 致病性致病性致病性

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