在印度人群中确定阿波脂蛋白-B和非高密度脂蛋白-C的目标:一个横截面研究
Parul Berry1, Ritvik Amarchand1, Lakshmy Ramakrishnan1
1CT Centre, AIIMS, Ansari Nagar, New Delhi, 110023, India.
这项研究为印度人口确定了Apolipoprotein-B (Apo-B) 和非高密度脂蛋白胆固醇 (非HDL-C) 的新切断值. 这些脂质标对于准确的心血管风险评估至关重要,特别是在 triglycerides 高的个体.
科学领域:
- 心血管医学 心血管医学
- 脂质代谢 脂质代谢是什么
- 公共卫生 公共卫生
背景情况:
- 低密度脂蛋白胆固醇 (LDL-C) 标单独可能错误地分类印度人的心血管风险,原因是高高三糖血和小密度的LDL-C颗粒.
- 国际指导方针建议使用Apolipoprotein-B (Apo-B) 和非高密度脂蛋白胆固醇 (非HDL-C) 作为替代性脂质标.
- 这项研究解决了印度对特定人群脂质标的需求.
研究的目的:
- 为了确定印度人群特有的Apolipoprotein-B (Apo-B) 和非高密度脂蛋白胆固醇 (非HDL-C) 的切割值.
- 将这些值与已确定的低密度脂蛋白胆固醇 (LDL-C) 目标相关联.
- 为了与国际指导方针进行比较,特别是对于 triglycerides 高的人来说.
主要方法:
- 利用了来自城市德里和农村Ballabhgarh的横截面人口数据库,包括3047个人.
- 使用斯皮尔曼相关性来评估Apo-B,非HDL-C和LDL-C之间的关系.
- 应用接收机操作员曲线分析,以确定Apo-B和非HDL-C的截止值,与指南推的LDL-C目标相比.
主要成果:
- 在Apo-B和LDL-C (0.82) 和非HDL-C和LDL-C (0.93) 之间发现了显著的相关性.
- 针对Apo-B和非HDL-C的特定人群截止值与LDL-C目标 (55-160 mg/dL) 相对应.
- 在高于150毫克/分升的甘油三水平的人群中,建议的Apo-B和非HDL-C值明显高于国际建议.
结论:
- 为印度患者提供特定的Apo-B和非HDL-C切线,有助于准确的心血管风险分层.
- 突出显示,高甘油三水平的印度人的Apo-B水平往往超过国际指导值.
- 强调特定于人口的脂质标对印度有效预防心血管疾病的重要性.
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