激酶非活性SLK的表达是胚胎致命的,并损害了纤维细胞中的细胞迁移

Samuel V Delisle1, Cedrik Labreche1, Mónica Lara-Márquez2

  • 1Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada.

概括

氨酸/氨酸激酶SLK (STK2) 有激酶独立的功能. 一个酶死亡的SLKK63R等位基因表明,至少50%的酶活性足以促进小鼠胚胎发育.

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