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葡萄糖皮质类药物对脂肪组织可塑性的影响

Anna Vali¹, Carine Beaupère¹, Alya Loubaresse¹

¹Centre de recherche Saint-Antoine (CRSA), Sorbonne université, Inserm, 75012 Paris, France; Institute of Cardiometabolism and Nutrition (ICAN), Sorbonne université, Inserm, 75013 Paris, France.

Annales d'endocrinologie

|June 13, 2024

概括

葡萄糖皮质类药物 (GCs) 影响新陈代谢和免疫力. 删除脂肪细胞中的GC受体 (GR) 改善了新陈代谢健康和胰岛素敏感性,尽管脂肪增加,显示GRGR.

科学领域:

内分泌学在内分泌学.
代谢生理学代谢生理学
脂肪组织生物学脂肪组织生物学

背景情况:

葡萄糖皮质醇 (GCs) 对于代谢适应和免疫功能至关重要,广泛用于炎症条件.
长期或高剂量的GC使用可能会导致诸如GC诱导的糖尿病和脂质营养不良等不良影响.
关于脂肪细胞特异性GC受体 (GR) 缺失的先前研究由于补偿机制导致了相互矛盾的结果.

研究的目的:

研究脂肪细胞GR在代谢适应和GC诱导的副作用中的特定作用.
使用可诱导的小鼠模型来绕过发育补偿问题.
阐明脂肪细胞GR对脂肪组织生理学和能量恒温的影响.

主要方法:

产生一种可诱导的脂肪细胞特异性GR淘汰 (AdipoGR-KO) 鼠标模型.
在AdipoGR-KO小鼠和对照 littermates中诱导高皮质主义.
评估葡萄糖耐受性,胰岛素敏感性,脂质概况和脂肪组织血管化.

主要成果:

在高皮质症下,AdipoGR-KO小鼠表现出改善的葡萄糖耐受性和胰岛素敏感性.
尽管显著增加了脂肪,但在AdipoGR-KO小鼠中,脂质谱发生了有利的变化.
在AdipoGR-KO小鼠中,脂肪组织的血管化增加,这表明GR抑制了健康的脂肪扩张.

结论:

脂肪细胞GR在调解GC诱导的代谢障碍方面发挥着关键作用.
向脂肪细胞GR可能为管理GC副作用提供治疗潜力.
脂肪细胞GR影响脂肪组织扩张和血管化,影响整体能量恒温.

关键词:

脂肪组织的脂肪组织.库辛综合症 (Cushing's Syndrome) 是一个疾病,葡萄糖皮质类药物是什么胰岛素耐药性胰岛素耐药性是一种血管化血管化

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