关节脂肪组织在骨关节炎中的作用
Natalia Zapata-Linares1, Francis Berenbaum2, Xavier Houard1
1Centre de recherche Saint-Antoine (CRSA), Sorbonne université, Inserm, 75012 Paris, France.
Annales d'endocrinologie
|June 13, 2024
概括
局部脂肪组织 (AT),包括关节内AT (IAAT) 和骨髓AT (BMAT),在关节健康和骨关节炎 (OA) 中起着至关重要的作用. IAAT在OA炎症和疼痛中起着关键作用,而BMAT在OA炎症和疼痛中起着关键作用.
科学领域:
- 整形外科和风湿病学
- 脂肪组织生物学 脂肪组织生物学
- 肌肉骨疾病的病理生理学
背景情况:
- 骨关节炎 (OA) 是一种普遍的肌肉骨疾病,没有治愈.
- 肥胖是OA的主要可改变的风险因素,突出显示了脂肪组织 (AT) 的作用.
- 局部AT,特别是关节内AT (IAAT) 和骨髓AT (BMAT),越来越多地被认为具有关节特异性的功能.
研究的目的:
- 审查IAAT和BMAT在关节稳态和OA中的已知特征和参与.
- 为了突出最近的发现,关于皮下脂肪的预测价值,在膝盖OA.改变膝盖OA.
- 根据其局部化和功能,探索BMAT在OA病变发生中的潜在作用.
主要方法:
- 对关节组织中IAAT和BMAT现有研究的文献综述.
- 对有关磁共振成像 (MRI) 信号强度在OA预测中的最新发现的分析.
- 关于BMAT与其微环境的相互作用及其在骨代谢中的作用的信息综合.
主要成果:
- 皮下脂肪MRI信号强度的变化可以预测膝关节OA的发展和进展.
- IAAT与突膜有功能联系,在突膜炎症,纤维化和OA疼痛中起到早期作用.
- BMAT体积和分子形状适应病理生理学环境,调节血液形成和骨代谢.
结论:
- IAAT是OA病变的早期和关键参与者,特别是在炎症和疼痛方面.
- 尽管BMAT在OA中的作用未得到充分研究,但由于其位置,功能和与OA骨重塑过程的相互作用,BMAT可能参与其中.
- 进一步研究BMAT的作用是有必要的,以了解其对OA的贡献,并确定潜在的治疗点.
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