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S-PRG填充剂对质细胞样细胞的牙周效应

Igor Paulino Mendes Soares¹, Caroline Anselmi², Lídia de Oliveira Fernandes³

¹Department of Dental Materials and Prosthodontics, São Paulo State University (UNESP), School of Dentistry, Araraquara, Brazil.

Dental materials : official publication of the Academy of Dental Materials

|June 13, 2024

概括

表面反应的预反应玻璃离子体 (S-PRG) 填充剂不会通过牙损害牙细胞样细胞. 长期暴露于S-PRG会促进牙生成活性和矿化,这表明它对牙纸细胞具有生物活性作用.

科学领域:

生物材料科学生物材料科学
牙纸生物学牙纸生物学
细胞毒理学细胞毒理学

背景情况:

表面反应预反应玻璃离子体 (S-PRG) 填充剂用于牙科修复.
了解它们对纸细胞的跨牙效应对于安全性和有效性至关重要.

研究的目的:

为了研究S-PRG填充剂化物对牙细胞类细胞 (MDPC-23) 的跨牙效应.
评估S-PRG化物暴露时间对细胞活力,形态,基因表达和矿物化的影响.

主要方法:

带有种子MDPC-23细胞的牙盘被暴露在S-PRG化物中1分钟或30分钟.
细胞活力,形态,基因表达 (Col1a1,Alpl,DSpp,Dmp1) 和矿物化在经牙扩散后进行了评估.

主要成果:

酸S-PRG在牙盘内的细胞上没有引起显著的细胞毒性.
较长时间的S-PRG化物暴露 (30分钟) 略微增加了细胞活力,并显著上调了牙基因表达.
30分钟的S-PRG治疗刺激了矿化活性39.7%.

结论:

S-PRG填充剂化物对质细胞类细胞没有经体细胞毒性.
持续暴露于S-PRG化物可以促进与牙相关的矿化活性,这表明牙纸对牙纸有潜在的生物活性益处.

关键词:

生物矿物化生物矿物化细胞存活率细胞存活率牙上的牙.离子离子是一种离子.它们是Odontoblasts.有毒性有毒性

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