体重增加和抗逆转录病毒疗法
Samuel S Bailin1, John R Koethe1
1Division of Infectious Diseases, Vanderbilt University Medical Center, 1161 21st Avenue South, A2200 Medical Center North, Nashville, TN 37232, USA.
Infectious disease clinics of North America
|June 13, 2024
概括
抗逆转录病毒疗法 (ART) 可以影响艾滋病毒感染者 (PWH) 的体重. 本综述研究了不同的ART药物如何影响体重,并讨论了管理PWH体重变化的方法.
科学领域:
- 传染性疾病 传染性疾病
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 对于接受抗逆转录病毒疗法 (ART) 的人类免疫缺陷病毒 (PWH) 患者来说,体重变化是一个重大问题.
- 新出现的证据表明,某些ART药物具有抑制体重的特性,这促使人们重新评估它们对体重的影响.
- 了解ART和体重之间的关系对于优化治疗和患者结果至关重要.
研究的目的:
- 综合当前关于在ART-naïve和ART-experiencedPWH中体重的决定因素的文献.
- 审查PWH中与肥胖和脂肪相关的因素.
- 探索与ART相关的体重增加的代谢后果和临床管理策略.
主要方法:
- 系统审查最近的科学文献.
- 对研究ART药物对体重的影响的研究分析.
- 检查脂肪和代谢变化的临床测量.
主要成果:
- 特定的ART药物,如efavirenz和tenofovirdisoproxil fumarate,已经显示出抑制体重的作用.
- 其他ART药物可能与体重增加有关,需要仔细考虑.
- 在PWH中代谢并发症和体重增加的临床管理是复杂的和多因素的.
结论:
- 在PWH中,ART疗法在调节体重方面发挥着至关重要的作用.
- 需要进一步的研究来阐明ART诱导的体重变化背后的机制,并制定有针对性的干预措施.
- 个性化管理策略对于解决ART上的PWH体重问题至关重要.
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