转移性结直肠癌的症状伪进展
Kasen Hutchings1, Ajlan Al Zaki2, Nishin Bhadkamkar2,3
1Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
BMJ case reports
|June 13, 2024
概括
在转移性结直肠癌中,伪进展可以在成像上模仿疾病恶化. 持续的 pembrolizumab 免疫疗法导致了患者的显著改善,强调了考虑伪进展的重要性.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 结肠直肠癌研究研究
背景情况:
- 转移性结直肠癌 (mCRC) 带来了重大的治疗挑战.
- 免疫疗法,如 pembrolizumab,为mCRC治疗提供了一个新的途径.
- 准确评估治疗反应对于优化患者的治疗结果至关重要.
研究的目的:
- 在接受 pembrolizumab.com 的转移性结直肠癌患者中调查疑似伪进展的病例.
- 评估持续免疫治疗的临床和放射性反应,尽管最初对疾病进展的担忧.
主要方法:
- 一名患有mCRC的患者接受了两轮的pembrolizumab.
- 临床症状和成像研究表明潜在的疾病进展.
- 伪进展被认为是一种差异诊断.
- 决定继续使用pembrolizumab进行第三个周期.
主要成果:
- 患者在第三轮 pembrolizumab治疗后出现了显著的症状改善.
- 放射性发现和可触摸的质量下降,表明瘤反应.
- 持续的免疫治疗导致持续的症状和放射性改善.
结论:
- 在接受免疫治疗的转移性结直肠癌患者中可能发生伪进展.
- 持续的 pembrolizumab 治疗可以在伪进展的情况下带来有利的结果.
- 仔细评估至关重要,以区分真正的进展与伪进展,以优化治疗策略.
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