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对女性BRCA突变载体的决策辅助:范围审查

Sarah A McGarrigle^1,2, Geraldine Prizeman³, Carol Spillane²

¹Faculty of Health Sciences, Trinity College Dublin, Dublin, Ireland.

|June 13, 2024

概括

决策辅助器 (DAs) 帮助BRCA突变女性管理癌症风险. 这次审查对现有的DA进行了映射,发现很少有专门针对未受影响的BRCA载体,尽管那些经过测试的人显示出积极的影响.

科学领域:

遗传学和基因组学遗传学和基因组学
在瘤学瘤学.
健康决策科学医疗科学

背景情况:

患有病原性BRCA1或BRCA2突变的女性面临显著增加的乳腺癌和卵巢癌风险.
有效的癌症风险管理策略存在,但对于这些人来说,选择它们是复杂的.
决策辅助工具 (DA) 是帮助患者做出明智的健康决策的关键工具.

研究的目的:

进行范围审查,对患者决策辅助工具 (DA) 的开发和测试的证据进行映射.
为了确定专门设计用于未受癌症影响的BRCA突变载体的DA.
了解当前DAs管理遗传癌症风险的现状.

主要方法:

根据Joanna Briggs Institute (JBI) 的方法框架进行了全面的范围审查.
在多个数据库 (MEDLINE,EMBASE,CINAHL,Web of Science) 进行了广泛的文献搜索,没有日期或语言限制.
数据提取涉及标准化的JBI仪器,由两名研究人员进行独立审查.

主要成果:

审查确定了32个证据来源,详细介绍了21个DA的开发或测试.
只有四个DA专门开发用于未受癌症影响的BRCA突变载体;一个是公开提供的.
所有研究有效性的药物都对至少一个结果产生了积极影响,尽管只有六项经过随机对照试验.

结论:

本范围审查提供了关于开发和测试癌症未受影响的BRCA突变载体的DA的文献的全面概述.
需要更容易获得的,经过严格测试的,针对这一特定人群量身定制的DA.
对DA的进一步研究和开发可以在癌症风险管理决策中赋予BRCA载体权力.

关键词:

癌症遗传学癌症遗传学决策是做出决策的过程.护理护理护理护理以患者为中心的护理.

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