尼古丁胺胺 рибо对外围动脉疾病:NICE随机临床试验
Mary M McDermott1,2, Christopher R Martens3, Kathryn J Domanchuk4
1Northwestern University Feinberg School of Medicine, Department of Medicine, Chicago, IL, USA. mdm608@northwestern.edu.
尼古丁胺 рибоoside (NR) 补充剂显著改善了周围动脉疾病 (PAD) 患者的步行距离. Resveratrol没有增强单独NR改善PAD症状的好处.
科学领域:
- 生物医学科学 生物医学科学
- 临床研究是临床研究.
- 营养科学 营养科学
背景情况:
- 周围动脉疾病 (PAD) 的特点是氧化应激增加,线粒体功能障碍和步行能力降低.
- 尼古丁胺胺氨基二核酸 (NAD+) 在降低氧化应激和支持线粒体呼吸方面发挥着至关重要的作用.
- 众所周知,口服尼古丁胺 рибоoside (NR) 可以增加人类的NAD+生物可用性.
研究的目的:
- 研究NR补充剂的有效性,有或没有白醇,改善PAD患者的行走表现.
- 评估NR对PAD患者氧化应激和线粒体活性的影响.
- 在一项随机对照试验中,比较NR和NR加Resveratrol与安慰剂的影响.
主要方法:
- 一个随机,双盲,安慰剂控制的临床试验,涉及90名患有PAD的参与者.
- 参与者接受了NR,NR加复星或安慰剂六个月.
- 主要结局指标是6个月后6分钟步行距离的变化.
主要成果:
- 与安慰剂相比,NR补充剂显著改善了6分钟的步行距离 (组间差异:+17.6米).
- 在高度坚持 (≥75%的药片摄入量) 的参与者中,NR改善了31.0米的步行距离,NR + 复星提高了26.9米.
- 当与NR相结合时,resveratrol没有为改善PAD的步行距离提供额外的益处.
结论:
- 口服NR补充剂在患有外周动脉疾病的个体中显著改善了行走性能.
- 在这个PAD队列中,复星似乎没有增强NR对步行距离的积极影响.
- 需要进一步的大规模临床试验来证实这些发现,并探索NR在PAD管理中的治疗潜力.
更多相关视频
04:44Author Spotlight: Enhancing Vascular Function and Physical Capacity in Cardiovascular Disease Through Novel Interventions and NIRS Technology
Published on: March 22, 2024
10:50Osmotic Drug Delivery to Ischemic Hindlimbs and Perfusion of Vasculature with Microfil for Micro-Computed Tomography Imaging
Published on: June 29, 2013
相关概念视频
Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Antianginal Drugs: Calcium Channel Blockers and Ranolazine
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
